TOMM34
TOMM34 Gene Summary
The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TOMM34 |
| Official Name | translocase of outer mitochondrial membrane 34 [Source:HGNC Symbol;Acc:HGNC:15746] |
| Ensembl ID | ENSG00000025772 |
| Bio databases IDs | |
| Aliases | translocase of outer mitochondrial membrane 34, outer mitochondrial membrane translocase (34kD) |
| Synonyms | 2610100K07RIK,HTOM34P,TOM34,translocase of outer mitochondrial membrane 34,URCC3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tetratricopeptide repeats
- heat shock protein binding
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the TOMM34 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- DYRK1A
- RPA1
- MRPS18C
- COL10A1
- BRD4
- TRIM25
- VCP
- PEA15
- MOV10
- MRPL38
disease
- colon cancer
regulated by
- sodium arsenite
- Caco2 cells
- GARS1
- GRIN3A
- tetrodotoxin
- MPST
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TOMM34 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- mitochondrial outer membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- heat shock protein binding
- protein binding