DAPK2 Gene Summary [Human]
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DAPK2 |
| Official Name | death associated protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:2675] |
| Ensembl ID | ENSG00000035664 |
| Bio databases IDs | |
| Aliases | death associated protein kinase 2 |
| Synonyms | death-associated protein kinase 2, DRP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAPK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- calmodulin binding
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- calmodulin regulatory domain
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the DAPK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- Alzheimer disease
- ulcerative colitis
- venous thromboembolism
- acute coronary syndrome
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- productive infection by HIV-1
role in cell
- apoptosis
- fragmentation
- growth
- blebbing
- anoikis
- 5-fluorouracil resistance
- migration by
- autophagy by
- replication in
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAPK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of intrinsic apoptotic signaling pathway
- positive regulation of neutrophil chemotaxis
- regulation of autophagy
- positive regulation of apoptotic process
- apoptotic process
- protein autophosphorylation
- anoikis
- regulation of apoptotic process
- protein phosphorylation
- positive regulation of eosinophil chemotaxis
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- autophagic vacuole lumen
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- identical protein binding
- protein binding
- protein serine/threonine kinase activity