BCAN Gene Summary [Human]
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | BCAN |
| Official Name | brevican [Source:HGNC Symbol;Acc:HGNC:23059] |
| Ensembl ID | ENSG00000132692 |
| Bio databases IDs | |
| Aliases | brevican, chondroitin sulfate proteoglycan 7, brevican proteoglycan |
| Synonyms | ALPBRE, BCAN isoform 1, BEHAB, Brevican, CSPG7, LOC100910284 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCAN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Human growth factor-like EGF
- hyaluronan binding domain
- central domain
- G1-domain
- Extracellular link domain
- protein binding
- EGF-like domain
- EGF_CA
- CCP
- core
- Link_Domain
- Immunoglobulin like
- Lectin C-type domain
- Sushi repeat (SCR repeat)
- complement regulatory protein domain
- G3 domain
- Immunoglobulin V-set domain
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic fatigue syndrome
- carcinoma in situ
- epithelial cancer in situ
- proliferative diabetic retinopathy
- glioblastoma cancer
role in cell
- growth
- expression in
- adhesion
- formation
- outgrowth
- activation in
- maturation
- invasion
- stabilization
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- Golgi lumen
- glutaminergic synapse
- axon component
- cell surface
- cellular membrane
- synaptic membrane
- lysosomal compartment
- nodes of Ranvier
- axon initial segments
- synapse
- extracellular matrix
- perikaryon
- axons
- dendrites
- perineuronal net
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCAN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- central nervous system development
- synapse maturation
- positive regulation of neuroblast proliferation
- cell adhesion
- hippocampus development
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- lysosomal lumen
- perineuronal net
- synapse
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hyaluronic acid binding
- carbohydrate binding