CTPS2 Gene Summary [Human]
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | CTPS2 |
| Official Name | CTP synthase 2 [Source:HGNC Symbol;Acc:HGNC:2520] |
| Ensembl ID | ENSG00000047230 |
| Bio databases IDs | |
| Aliases | CTP synthase 2 |
| Synonyms | A830031M15RIK, Ctpsh, CTP synthase 2, cytidine 5'-triphosphate synthase 2, GATD5B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CTPS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTP binding site
- Glutamine amidotransferase class-I
- CTP synthase N-terminus
- CTP synthase
- enzyme
- protein binding
- identical protein binding
- Type 1 glutamine amidotransferase (GATase1)-like domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CTPS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CTP biosynthetic process
- 'de novo' CTP biosynthetic process
- glutamine metabolic process
- pyrimidine nucleotide metabolic process
- pyrimidine base biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoophidium
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- CTP synthase activity