ARHGEF5 Gene Summary [Human]
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARHGEF5 |
| Official Name | Rho guanine nucleotide exchange factor 5 [Source:HGNC Symbol;Acc:HGNC:13209] |
| Ensembl ID | ENSG00000050327 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 5, transforming immortalized mammary oncogene, guanine nucleotide regulatory protein TIM, ephexin3 |
| Synonyms | 2210412D05RIK, AC243837.3, GEF5, P60, Rho guanine nucleotide exchange factor 5, TIM, TIM1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGEF5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- RhoGEF
- RhoGEF 5/35 N-terminal disordered region
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the ARHGEF5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- breast carcinoma
- prostatic carcinoma
- prostate cancer
- breast cancer
- ovarian carcinoma
- epithelial ovarian cancer
role in cell
- loss
- activation in
- loss in
- formation
- number
- chemotaxis
- homeostasis
- migration
- function
- chemotaxis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGEF5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of ERK1 and ERK2 cascade
- regulation of actin cytoskeleton organization
- positive regulation of stress fiber assembly
- regulation of small GTPase mediated signal transduction
- regulation of cytoskeleton organization
- regulation of GTPase activity
- myeloid dendritic cell chemotaxis
- actin cytoskeleton organization
- positive regulation of podosome assembly
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- anchoring junction
- cytoplasm
- cytosol
- cell projection
- plasma membrane
- podosome
- nucleoplasm
- cell periphery
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- guanyl-nucleotide exchange factor activity
- lipid binding