FNIP1 Gene Summary [Human]
This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Details
| Type | Protein Coding |
| Official Symbol | FNIP1 |
| Official Name | folliculin interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29418] |
| Ensembl ID | ENSG00000217128 |
| Bio databases IDs | |
| Aliases | folliculin interacting protein 1 |
| Synonyms | A730024A03Rik, folliculin interacting protein 1, IMD93 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FNIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Folliculin-interacting protein C-terminus
- Folliculin-interacting protein N-terminus
- ATPase inhibitor activity
- Folliculin-interacting protein middle domain
- enzyme binding
- protein binding
- chaperone binding
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- fatigue
- critical COVID-19
- systemic lupus erythematosus
- immunodeficiency 93 and hypertrophic cardiomyopathy
- FNIP1 deficiency
- inflammatory bowel disease
- renal neoplasia
- agammaglobulinemia
- cardiomyopathy
regulated by
- beta-estradiol
- inosine
- levodopa
- ESRP1
role in cell
- apoptosis
- phosphorylation in
- expression in
- proliferation
- differentiation
- quantity
- activation in
- development
- number
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FNIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- negative regulation of cell proliferation
- TOR signaling cascade
- cellular response to starvation
- B cell apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- immature B cell differentiation
- regulation of protein phosphorylation
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of protein phosphorylation
- regulation of pro-B cell differentiation
- positive regulation of B cell apoptotic process
- negative regulation of TOR signaling cascade
- positive regulation of TOR signaling cascade
- positive regulation of protein complex assembly
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase inhibitor activity
- metal ion binding
- chaperone binding
- enzyme activator activity
- enzyme binding