LAMTOR5 Gene Summary [Human]
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LAMTOR5 |
| Official Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [Source:HGNC Symbol;Acc:HGNC:17955] |
| Ensembl ID | ENSG00000134248 |
| Bio databases IDs | |
| Aliases | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5, HBx-interacting protein, hepatitis B virus x-interacting protein (9.6kD) |
| Synonyms | 1110003H18RIK, HBXIP, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5, XIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LAMTOR5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ragulator complex protein LAMTOR5
- guanyl-nucleotide exchange factor
- leucine zipper domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- urogenital cancer
- breast cancer
- breast carcinoma
- breast or ovarian cancer
- impaired glucose tolerance
role in cell
- expression in
- growth
- proliferation
- activation in
- migration
- apoptosis
- formation
- invasion by
- size
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Nucleus
- lysosome
- cytosol
- lysosome membrane
- centrosomal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LAMTOR5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- cellular response to amino acid stimulus
- positive regulation of interleukin-8 production
- positive regulation of gene expression
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- regulation of cell size
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- viral genome replication
- response to virus
- positive regulation of TOR signaling cascade
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- cytosol
- Ragulator complex
- macromolecular complex
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- binding, bridging