ENTPD2 Gene Summary [Human]
The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | ENTPD2 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3364] |
| Ensembl ID | ENSG00000054179 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 2, CD39-like-1, ecto-ATPase |
| Synonyms | Ca2+/Mg2+ ecto-ATPase, CD39L1, Ectonucleoside triphosphate diphosphohydrolase, ectonucleoside triphosphate diphosphohydrolase 2, NTPDase-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENTPD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- nucleoside-diphosphatase
- apyrase
- enzyme
- protein binding
- identical protein binding
- ATPase
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the ENTPD2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe COVID-19
- neoplasia
- phobic anxiety disorder
- plexiform neurofibroma
role in cell
- expression in
- activation
- formation in
- degradation in
- response by
- hydrolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell surface
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- apical cell surfaces
- basolateral cell surfaces
- trans Golgi network
- cellular protrusions
- perikaryon
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENTPD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside diphosphate catabolic process
- G-protein coupled receptor signaling pathway
- purine ribonucleoside diphosphate catabolic process
- platelet activation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- basement membrane
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- uridine-diphosphatase activity
- guanosine-diphosphatase activity
- nucleoside-triphosphatase activity