Entpd2 Gene Summary [Mouse]
Enables nucleoside diphosphate phosphatase activity and ribonucleoside triphosphate phosphatase activity. Acts upstream of or within G protein-coupled receptor signaling pathway; platelet activation; and purine ribonucleoside diphosphate catabolic process. Located in basement membrane and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Entpd2 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 2 [Source:MGI Symbol;Acc:MGI:1096863] |
| Ensembl ID | ENSMUSG00000015085 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 2 |
| Synonyms | Ca2+/Mg2+ ecto-ATPase, CD39L1, Ectonucleoside triphosphate diphosphohydrolase, ectonucleoside triphosphate diphosphohydrolase 2, NTPDase-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Entpd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- nucleoside-diphosphatase
- apyrase
- enzyme
- protein binding
- identical protein binding
- ATPase
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Entpd2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe COVID-19
- neoplasia
- phobic anxiety disorder
- plexiform neurofibroma
role in cell
- expression in
- activation
- formation in
- degradation in
- response by
- hydrolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell surface
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- apical cell surfaces
- basolateral cell surfaces
- trans Golgi network
- cellular protrusions
- perikaryon
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Entpd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside diphosphate catabolic process
- G-protein coupled receptor signaling pathway
- purine ribonucleoside diphosphate catabolic process
- platelet activation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- basement membrane
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- uridine-diphosphatase activity
- guanosine-diphosphatase activity
- nucleoside-triphosphatase activity