GPC1 Gene Summary [Human]
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GPC1 |
| Official Name | glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449] |
| Ensembl ID | ENSG00000063660 |
| Bio databases IDs | |
| Aliases | glypican 1, glypican proteoglycan 1 |
| Synonyms | glypican, GLYPICAN-1, HSPG M12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- copper ion binding
- Glypican
- fibroblast growth factor binding
- laminin binding
- collagen binding
- protein binding
- transmembrane receptor
- glycosylphosphatidylinositol anchor sequence
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic neoplasia
- early missed abortion
- prostate cancer
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
- schizophrenia
- brachydactyly mental retardation syndrome
role in cell
- cell death
- production in
- expression in
- phosphorylation in
- proliferation
- growth
- invasion by
- migration
- formation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Golgi lumen
- intracellular compartment
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- cytosol
- lysosomal compartment
- nucleoplasm
- perinuclear space
- synapse
- extracellular matrix
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Schwann cell differentiation
- negative regulation of fibroblast growth factor receptor signaling pathway
- positive regulation of skeletal muscle cell differentiation
- heparan sulfate proteoglycan catabolic process
- myelin assembly
- cell migration
Cellular Component
Where in the cell the gene product is active
- lysosomal lumen
- synapse
- extracellular region
- Golgi lumen
- plasma membrane
- cell surface
- nucleoplasm
- extracellular space
- extracellular vesicular exosome
- endosome
- membrane raft
- cytosol
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- fibroblast growth factor binding
- laminin binding