CCNB1 Gene Summary [Human]
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | CCNB1 |
| Official Name | cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] |
| Ensembl ID | ENSG00000134057 |
| Bio databases IDs | |
| Aliases | cyclin B1, G2/mitotic-specific cyclin B1 |
| Synonyms | CCNB, CCNB1-RS1, Ccnb1-rs13, CycB1, Cycb1-rs1, Cycb-4, Cycb-5, CYCLIN B, CYCLIN B1, Cyclin b4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin box
- protein kinase
- protein kinase binding
- nuclear export signal
- Cyclin box fold superfamily
- nuclear localization sequence
- enzyme binding
- enzyme
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- cytoplasmic sequestration domain
- cyclin-dependent protein kinase regulator
- protein kinase activator
- kinase
- P-box
- binding protein
- destruction box
- Cyclin, N-terminal domain
- patched binding
Pathways
Biological processes and signaling networks where the CCNB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- non-small cell lung cancer
- colon adenocarcinoma
- prostate cancer
- transitional cell bladder cancer
- squamous cell lung cancer
- gastric adenocarcinoma
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- expression in
- production in
- quantity
- growth
- phosphorylation in
- apoptosis
- upregulation in
- proliferation
- damage in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- detergent resistant lipid raft fraction
- spindle apparatus
- cell surface
- perinuclear region
- cellular membrane
- ribosome
- Nucleus
- centrosome
- centriole
- Mitochondria
- microtubules
- cytosol
- mitochondrial matrix
- nucleoplasm
- nuclear rim
- spindle pole
- spindle fibers
- mitotic spindle
- kinetochores
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCNB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- G2/M transition of mitotic cell cycle
- in utero embryonic development
- mitotic spindle organization
- positive regulation of fibroblast proliferation
- regulation of mitotic cell cycle spindle assembly checkpoint
- positive regulation of attachment of spindle microtubules to kinetochore
- mitotic metaphase plate congression
- positive regulation of mitotic cell cycle
- positive regulation of G2/M transition of mitotic cell cycle
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cyclin B1-CDK1 complex
- mitochondrial matrix
- cytoplasm
- membrane
- spindle pole
- cytosol
- condensed chromosome outer kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- cyclin-dependent protein kinase regulator activity
- small conjugating protein ligase binding
- patched binding