INTS13 Gene Summary [Human]
Involved in regulation of mitotic cell cycle. Acts upstream of or within centrosome localization; mitotic spindle organization; and protein localization to nuclear envelope. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | INTS13 |
| Official Name | integrator complex subunit 13 [Source:HGNC Symbol;Acc:HGNC:20174] |
| Ensembl ID | ENSG00000064102 |
| Bio databases IDs | |
| Aliases | integrator complex subunit 13, spermatogenesis associated 30 |
| Synonyms | 4933424B01Rik, ASUN, C12orf11, FLJ10637, GCT1, integrator complex subunit 13, LOC686480, Mat89Bb, NET48, SPATA30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INTS13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cell cycle and development regulator Mat89Bb
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INTS13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- cell division
- snRNA processing
- sperm motility
- regulation of transcription elongation from RNA polymerase II promoter
- regulation of fertilization
- mitotic spindle organization
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
- integrator complex
Molecular Function
What the gene product does at the molecular level
- protein binding