POLR2K Gene Summary [Human]
This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | POLR2K |
| Official Name | RNA polymerase II, I and III subunit K [Source:HGNC Symbol;Acc:HGNC:9198] |
| Ensembl ID | ENSG00000147669 |
| Bio databases IDs | |
| Aliases | RNA polymerase II, I and III subunit K |
| Synonyms | ABC10-alpha, ABC10-α, hRPB7.0, hsRPB10a, MafY, Mt1a, polymerase (RNA) II (DNA directed) polypeptide K, RNA polymerase II, I and III subunit K, RPABC4, RPB10alpha, Rpb10 α, RPB12, RPB7.0 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2K often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA directed RNA polymerase, 7 kDa subunit
- zinc ion binding
- DNA-directed RNA polymerase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the POLR2K gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- productive infection by HIV-1
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase I
- RNA polymerase II
- RNA polymerase iii
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2K gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase III activity
- RNA polymerase II activity
- zinc ion binding
- RNA polymerase I activity
- protein binding