HIPK2
HIPK2 Gene Summary
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | HIPK2 |
| Official Name | homeodomain interacting protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14402] |
| Ensembl ID | ENSG00000064393 |
| Bio databases IDs | |
| Aliases | homeodomain interacting protein kinase 2 |
| Synonyms | 1110014O20RIK,B230339E18RIK,homeodomain interacting protein kinase 2,LOC100505582,LOC653052,PRO0593,Stank |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- virion binding
- SMAD binding
- protein interaction domain
- protein serine/threonine kinase
- Homeodomain-interacting protein kinase domain
- Protein kinase (unclassified specificity)
- Axin binding domain
- protein kinase
- transcription co-activator
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- transcription co-repressor
- nuclear localization sequence
- transcription factor binding
- protein binding
- Protein kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- AT hook domain
- tail domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the HIPK2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- AR
- SPOP
- ACTBL2
- HNRNPL
- MDM2
- XAF1
- TP53
- AXIN1
- WSB1
- MDM4
disease
- hypertension
- lung cancer
- epithelial cancer
- cancer
- glioblastoma
- glioblastoma cancer
- melanoma cancer
- melanoma
- non-insulin-dependent diabetes mellitus
- sarcoma
regulated by
- hydrogen peroxide
- IL4
- SPOP
- ZYX
- TGFB1
- SENP2
- TNF
- cobalt chloride
- doxorubicin
- ubiquitin
regulates
- MAPK8
- RAC1
- RELA
- JNK
- IL6
- IL1B
- TNF
- AKT
- CASP3
- BDNF
role in cell
- survival
- apoptosis
- cell death
- growth
- cell viability
- binding in
- production in
- expression in
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
- midbody
- nuclear foci
- nucleoplasm
- nuclear bodies
- nuclear speckles
- stress granule
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HIPK2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation of protein binding
- positive regulation of cell proliferation
- anterior/posterior pattern specification
- transforming growth factor beta receptor signaling pathway
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- intrinsic apoptotic signaling pathway
- positive regulation of sequence-specific DNA binding transcription factor activity
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of angiogenesis
- negative regulation of neuron apoptotic process
- lung morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- adult walking behavior
- cellular response to hypoxia
- regulation of cell cycle
- neuron apoptotic process
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- neuron differentiation
- SMAD protein signal transduction
- smoothened signaling pathway
- embryonic retina morphogenesis in camera-type eye
- lens induction in camera-type eye
- regulation of gene expression, epigenetic
- respiratory system process
- negative regulation of BMP signaling pathway
- eye development
- thyroid gland development
- erythrocyte differentiation
- voluntary musculoskeletal movement
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- embryonic camera-type eye morphogenesis
- retina layer formation
- DNA damage response, signal transduction by p53 class mediator
- gene expression
- iris morphogenesis
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- PML body organization
- positive regulation of transforming growth factor beta receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasmic stress granule
- PML body
- cytoplasm
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- virion binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- transcription coactivator activity
- SMAD binding
- transcription corepressor activity
- protein kinase activity
- protein serine/threonine kinase activity