ERLEC1 Gene Summary [Human]
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Details
| Type | Processed Transcript |
| Official Symbol | ERLEC1 |
| Official Name | endoplasmic reticulum lectin 1 [Source:HGNC Symbol;Acc:HGNC:25222] |
| Ensembl ID | ENSG00000068912 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum lectin 1, erlectin 1 |
| Synonyms | 4933407N01Rik, C2orf30, CIM, CL24936, CL25084, endoplasmic reticulum lectin 1, HEL117, RGD1306508, XTP3-B, XTP3TPB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ERLEC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glucosidase II beta subunit-like protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ERLEC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
- retrograde protein transport, ER to cytosol
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum quality control compartment
Molecular Function
What the gene product does at the molecular level
- protein binding
- unfolded protein binding