P2RY6 Gene Summary [Human]
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | P2RY6 |
| Official Name | pyrimidinergic receptor P2Y6 [Source:HGNC Symbol;Acc:HGNC:8543] |
| Ensembl ID | ENSG00000171631 |
| Bio databases IDs | |
| Aliases | pyrimidinergic receptor P2Y6 |
| Synonyms | 2010204J23RIK, P2Y6, pyrimidinergic receptor P2Y6, pyrimidinergic receptor P2Y, G-protein coupled, 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- UTP-activated nucleotide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- platelet ADP receptor
- seven-transmembrane G protein-coupled receptor superfamily
- UDP-activated nucleotide receptor
Pathways
Biological processes and signaling networks where the P2RY6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- metastasis
- impaired glucose tolerance
- carcinoma in situ
- epithelial cancer in situ
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- experimentally induced bacterial peritonitis
- cardiac hypertrophy
- infection by Vesicular stomatitis Indiana virus
role in cell
- expression in
- phosphorylation in
- migration
- activation in
- activity
- production in
- maturation
- quantity
- replication in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- phagocytosis
- transepithelial chloride transport
- positive regulation of smooth muscle cell migration
- phospholipase C-activating G-protein coupled receptor signaling pathway
- cellular response to prostaglandin E stimulus
- cellular response to purine-containing compound
- G-protein coupled purinergic nucleotide receptor signaling pathway
- positive regulation of inositol trisphosphate biosynthetic process
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- UTP-activated nucleotide receptor activity
- G-protein coupled receptor activity
- ADP receptor activity
- protein binding
- UDP-activated nucleotide receptor activity