POLR2L Gene Summary [Human]
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | POLR2L |
| Official Name | RNA polymerase II, I and III subunit L [Source:HGNC Symbol;Acc:HGNC:9199] |
| Ensembl ID | ENSG00000177700 |
| Bio databases IDs | |
| Aliases | RNA polymerase II, I and III subunit L |
| Synonyms | 2510029B14Rik, hRPB7.6, LOC100911840, LOC682164, polymerase (RNA) II (DNA directed) polypeptide L, RBP10, RNA polymerase II, I and III subunit L, RPABC5, RPB10, RPB10beta, Rpb10 β, RPB7.6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- DNA-directed RNA polymerase
- RNA polymerases N / 8 kDa subunit
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the POLR2L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- hypertensive renal disease
- productive infection by HIV-1
regulates
- DNA endogenous promoter
- RNA polymerase II
- DNA promoter
- RNA polymerase I
role in cell
- survival
- growth
- replication in
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
- tRNA transcription from RNA polymerase III promoter
- regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- cytosol
- DNA-directed RNA polymerase III complex
- DNA-directed RNA polymerase II, core complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase III activity
- DNA binding
- RNA polymerase II activity
- zinc ion binding
- protein binding
- DNA-directed RNA polymerase activity
- RNA polymerase I activity