API5 Gene Summary [Human]
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | API5 |
| Official Name | apoptosis inhibitor 5 [Source:HGNC Symbol;Acc:HGNC:594] |
| Ensembl ID | ENSG00000166181 |
| Bio databases IDs | |
| Aliases | apoptosis inhibitor 5, API5-like 1, fibroblast growth factor 2-interacting factor 2, migration-inducing protein MIG8 |
| Synonyms | AAC-11, apoptosis inhibitor 5, FIF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human API5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibroblast growth factor binding
- protein binding
- HEAT repeats
- Apoptosis inhibitory protein 5 (API5)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- organismal death
- HER2-positive breast cancer
- luminal B breast cancer
- luminal A breast cancer
- basal-like breast cancer
role in cell
- expression in
- activation in
- phosphorylation in
- apoptosis
- migration
- proliferation
- growth
- degradation in
- dimerization in
- polarity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- spliceosomes
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human API5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast apoptotic process
- negative regulation of apoptotic process
- fibroblast apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- membrane
- spliceosomal complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- fibroblast growth factor binding