RPS6KA6 Gene Summary [Human]
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | RPS6KA6 |
| Official Name | ribosomal protein S6 kinase A6 [Source:HGNC Symbol;Acc:HGNC:10435] |
| Ensembl ID | ENSG00000072133 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase A6 |
| Synonyms | 2610524K04Rik, CR392009.1, p90-RSK 6, PP90RSK4, RGD1560817, ribosomal protein S6 kinase A6, ribosomal protein S6 kinase polypeptide 6, RSK-4, S6K-alpha-6, S6K-α-6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS6KA6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Protein tyrosine and serine/threonine kinase
- MAPK binding site
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the RPS6KA6 gene in human plays a role, providing insight into its function and relevance in health or disease.
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Growth Hormone Signaling
- Melanocyte Development and Pigmentation Signaling
- mTOR Signaling
- NGF Signaling
- Opioid Signaling Pathway
- p38 MAPK Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- phosphorylation in
- invasion by
- colony formation
- cell viability
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- Mitochondria
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPS6KA6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- central nervous system development
- negative regulation of embryonic development
- signal transduction
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of mesoderm development
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ribosomal protein S6 kinase activity
- ATP binding
- protein binding
- protein kinase activity