Rps6ka6 Gene Summary [Mouse]
Predicted to enable ribosomal protein S6 kinase activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of embryonic development; and negative regulation of mesoderm development. Is active in synapse. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps6ka6 |
| Official Name | ribosomal protein S6 kinase polypeptide 6 [Source:MGI Symbol;Acc:MGI:1914321] |
| Ensembl ID | ENSMUSG00000025665 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase polypeptide 6 |
| Synonyms | 2610524K04Rik, CR392009.1, p90-RSK 6, PP90RSK4, RGD1560817, ribosomal protein S6 kinase A6, ribosomal protein S6 kinase polypeptide 6, RSK-4, S6K-alpha-6, S6K-α-6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps6ka6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Protein tyrosine and serine/threonine kinase
- MAPK binding site
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Rps6ka6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Growth Hormone Signaling
- Melanocyte Development and Pigmentation Signaling
- mTOR Signaling
- NGF Signaling
- Opioid Signaling Pathway
- p38 MAPK Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- phosphorylation in
- invasion by
- colony formation
- cell viability
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- Mitochondria
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps6ka6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- central nervous system development
- negative regulation of embryonic development
- signal transduction
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of mesoderm development
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ribosomal protein S6 kinase activity
- ATP binding
- protein binding
- protein kinase activity