STK10 Gene Summary [Human]
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STK10 |
| Official Name | serine/threonine kinase 10 [Source:HGNC Symbol;Acc:HGNC:11388] |
| Ensembl ID | ENSG00000072786 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 10, lymphocyte-oriented kinase |
| Synonyms | GEK1, LOC107986477, LOK, mKIAA4026, PRO2729, serine/threonine kinase 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polo kinase kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Trichohyalin-plectin-homology domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- COVID-19
- migraines
- monomorphic epitheliotropic intestinal T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- type I enteropathy-associated T-cell lymphoma
- inflammatory bowel disease
- central nervous system cancer
role in cell
- expression in
- cell death
- function
- mesenchymal motility
- tension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- specific granule membrane
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lymphocyte aggregation
- protein autophosphorylation
- protein phosphorylation
- regulation of lymphocyte migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- protein serine/threonine kinase activity