Stk10 Gene Summary [Rat]
Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including lymphocyte aggregation; protein autophosphorylation; and regulation of lymphocyte migration. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human STK10 (serine/threonine kinase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stk10 |
| Official Name | serine/threonine kinase 10 [Source:RGD Symbol;Acc:3779] |
| Ensembl ID | ENSRNOG00000004217 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 10 |
| Synonyms | GEK1, LOC107986477, LOK, mKIAA4026, PRO2729, serine/threonine kinase 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stk10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polo kinase kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Trichohyalin-plectin-homology domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- COVID-19
- migraines
- monomorphic epitheliotropic intestinal T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- type I enteropathy-associated T-cell lymphoma
- inflammatory bowel disease
- central nervous system cancer
role in cell
- expression in
- cell death
- function
- mesenchymal motility
- tension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- specific granule membrane
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stk10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lymphocyte aggregation
- protein autophosphorylation
- protein phosphorylation
- regulation of lymphocyte migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- protein serine/threonine kinase activity