FERMT2 Gene Summary [Human]
Enables several functions, including actin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of cellular component biogenesis. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in cytosol; focal adhesion; and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Part of adherens junction and plasma membrane. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FERMT2 |
| Official Name | fermitin family member 2 [Source:HGNC Symbol;Acc:HGNC:15767] |
| Ensembl ID | ENSG00000073712 |
| Bio databases IDs | |
| Aliases | fermitin family member 2, FERM domain containing kindlin 2, kindlin-2, mitogen inducible gene-2 |
| Synonyms | AA960555, FERM domain containing kindlin 2, fermitin family member 2, KIND2, KINDLIN 2, MIG2, PLEKHC1, UNC112, UNC112B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FERMT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- protein kinase binding
- protein binding
- Pleckstrin homology-like domain
- integrin binding domain
- protein kinase activator
- FERM subdomain f3
- actin filament binding
- FERM domain
- actin-binding domain
- phosphatidylinositol-3,4,5-triphosphate binding
- actin binding
- Ubl1_cv_Nsp3_N-like
- transforming growth factor-beta receptor binding
- PH domain
- Kindlin-2 N-terminal domain
Pathways
Biological processes and signaling networks where the FERMT2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- neoplasia
- epithelial cancer
- COVID-19
- open-angle glaucoma
- hepatic steatosis
- obesity diabetes
- nonalcoholic fatty liver disease
- mammary neoplasm
- prostatic carcinoma
role in cell
- cell viability
- degradation in
- production in
- differentiation
- proliferation
- expression in
- growth
- migration
- invasion by
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cell junction
- cell-matrix contacts
- focal complexes
- focal adhesions
- Nucleus
- Plasma Membrane
- cell-cell contacts
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- actin stress fibers
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FERMT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- regulation of cell morphogenesis
- transforming growth factor beta receptor signaling pathway
- cell adhesion
- positive regulation of osteoblast differentiation
- positive regulation of GTPase activity
- positive regulation of epithelial to mesenchymal transition
- integrin-mediated signaling pathway
- substrate adhesion-dependent cell spreading
- Wnt receptor signaling pathway
- focal adhesion assembly
- positive regulation of protein localization to nucleus
- cell-matrix adhesion
- limb development
- negative regulation of fat cell differentiation
- positive regulation of substrate adhesion-dependent cell spreading
- negative regulation of vascular permeability
- positive regulation of focal adhesion assembly
- positive regulation of stress fiber assembly
- positive regulation of ERK1 and ERK2 cascade
- protein localization in membrane
- adherens junction maintenance
- positive regulation of myosin light chain kinase activity
- positive regulation of integrin activation
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- integrin activation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
- nucleoplasm
- internal side of plasma membrane
- nucleus
- adherens junction
- focal adhesion
- cytoplasm
- cell cortex
- stress fiber
- I band
- cell junction
- cytosol
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- actin filament binding
- protein kinase binding
- protein binding
- actin binding
- SMAD binding
- integrin binding
- type I transforming growth factor beta receptor binding