SLC25A3
SLC25A3 Gene Summary
The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC25A3 |
| Official Name | solute carrier family 25 member 3 [Source:HGNC Symbol;Acc:HGNC:10989] |
| Ensembl ID | ENSG00000075415 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 3 |
| Synonyms | 5730556H19Rik,OK/SW-cl.48,PHC,PiC,PTP,solute carrier family 25 member 3,solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphate:hydrogen symporter
- Mitochondrial carrier protein
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the SLC25A3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR2
- ESR1
- ERBB2
- BRD4
- HSPB1
- INSR
- FBXO7
- MAP1LC3B
- CFTR
- PIH1D1
disease
- Mitochondrial phosphate carrier deficiency
- nonalcoholic fatty liver disease
- lymphoma
- lymphomagenesis
- mitochondrial disorder
regulated by
- 5-fluorouracil
- MYB family
- tat-psi-delta-RACK
- mir-8 (includes others)
- myoblasts
- BAG3
- doxorubicin
- INSR
- TCR (complex)
- Gsta4
regulates
- BAX
role in cell
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cristae-like membrane
- cellular membrane
- Plasma Membrane
- Mitochondria
- myofilaments
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SLC25A3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- phosphate ion transmembrane transport
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- mitochondrion
- mitochondrial inner membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- inorganic phosphate transmembrane transporter activity
- phosphate:hydrogen symporter activity