Slc25a3 Gene Summary [Mouse]
Predicted to enable phosphate transmembrane transporter activity and phosphate:proton symporter activity. Predicted to be involved in phosphate ion transmembrane transport. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a3 |
| Official Name | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 [Source:MGI Symbol;Acc:MGI:1353498] |
| Ensembl ID | ENSMUSG00000061904 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 |
| Synonyms | 5730556H19Rik, OK/SW-cl.48, PHC, PiC, PTP, solute carrier family 25 member 3, solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphate:hydrogen symporter
- Mitochondrial carrier protein
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Slc25a3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Mitochondrial phosphate carrier deficiency
- nonalcoholic fatty liver disease
- lymphoma
- lymphomagenesis
- mitochondrial disorder
regulates
role in cell
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cristae-like membrane
- cellular membrane
- Plasma Membrane
- Mitochondria
- myofilaments
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- mitochondrion
- mitochondrial inner membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic phosphate transmembrane transporter activity
- phosphate:hydrogen symporter activity