SLC15A4 Gene Summary [Human]
Enables L-histidine transmembrane transporter activity; peptide transmembrane transporter activity; and peptidoglycan transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of toll-like receptor signaling pathway. Located in endolysosome membrane. Is integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC15A4 |
| Official Name | solute carrier family 15 member 4 [Source:HGNC Symbol;Acc:HGNC:23090] |
| Ensembl ID | ENSG00000139370 |
| Bio databases IDs | |
| Aliases | solute carrier family 15 member 4 |
| Synonyms | AW742963, C130069N12Rik, FP12591, LOC246280, PHT1, PTR4, solute carrier family 15 member 4, solute carrier family 15, member 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC15A4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amide transporter
- amino acid/peptide transporter (Peptide:H+ symporter), bacterial
- Major Facilitator Superfamily
- peptide:hydrogen symporter
- protein binding
- histidine transporter
- transporter
- peptidoglycan transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- colitis
- lupus erythematosus
- periarteritis
- systemic lupus erythematosus
- glomerulonephritis
- interstitial nephritis
- infection by lymphocytic choriomeningitis virus
role in cell
- expression in
- phosphorylation in
- production in
- activation in
- proliferation
- accumulation in
- quantity
- accumulation
- homeostasis
- pH regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- specific granule membrane
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC15A4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 8 signaling pathway
- mast cell homeostasis
- positive regulation of toll-like receptor 9 signaling pathway
- protein transport
- ion transport
- positive regulation of innate immune response
- regulation of isotype switching to IgG isotypes
- positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
- innate immune response
- histidine transport
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- regulation of nucleotide-binding oligomerization domain containing signaling pathway
- positive regulation of toll-like receptor 7 signaling pathway
- peptidoglycan transport
- peptide transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endolysosome membrane
- membrane
- lysosomal membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- dipeptide transmembrane transporter activity
- peptide:hydrogen symporter activity
- protein binding
- L-histidine transmembrane transporter activity
- peptidoglycan transporter activity