DAPK1 Gene Summary [Human]
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Details
| Type | Protein Coding |
| Official Symbol | DAPK1 |
| Official Name | death associated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:2674] |
| Ensembl ID | ENSG00000196730 |
| Bio databases IDs | |
| Aliases | death associated protein kinase 1 |
| Synonyms | D13Ucla1, DAPK, DAP-Kinase, death associated protein kinase 1, ROCO3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAPK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- protein serine/threonine kinase
- Ankyrin repeats (many copies)
- protein kinase
- cytoskeleton binding domain
- ATP binding
- Protein kinase domain
- identical protein binding
- Ankyrin repeat
- syntaxin-1 binding
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
- ankyrin repeats
- Protein kinase (unclassified specificity)
- calmodulin binding
- Protein tyrosine and serine/threonine kinase
- Ankyrin repeats (3 copies)
- calmodulin dependent protein kinase domain
- protein binding
- calmodulin regulated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Death Domain Superfamily of protein-protein interaction domains
- death domain binding domain
Pathways
Biological processes and signaling networks where the DAPK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- neoplasia
- metastasis
- progression free survival
- systemic lupus erythematosus
- chronic lymphocytic leukemia
- adenoma formation
- non-small cell lung carcinoma
- head and neck neuroendocrine neoplasia
- pituitary gland adenoma
role in cell
- expression in
- binding in
- activation in
- proliferation
- production in
- binding
- apoptosis
- cell death
- autophagy
- blebbing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- actin cytoskeleton
- Plasma Membrane
- cytosol
- neurites
- postsynaptic density
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAPK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- apoptotic signaling pathway
- regulation of apoptotic process
- induction of apoptosis via death domain receptors
- protein phosphorylation
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of autophagy
- defense response to tumor cell
- regulation of response to tumor cell
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- apoptotic process
- regulation of autophagy
- cellular response to hydroperoxide
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
- cellular response to interferon-gamma
- negative regulation of translation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- cytoplasm
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- calmodulin binding
- identical protein binding
- protein binding
- syntaxin-1 binding
- calmodulin-dependent protein kinase activity
- protein kinase activity
- protein serine/threonine kinase activity