GIPC1 Gene Summary [Human]
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | GIPC1 |
| Official Name | GIPC PDZ domain containing family member 1 [Source:HGNC Symbol;Acc:HGNC:1226] |
| Ensembl ID | ENSG00000123159 |
| Bio databases IDs | |
| Aliases | GIPC PDZ domain containing family member 1 |
| Synonyms | C19orf3, GIPC, GIPC PDZ domain containing family member 1, GIPC PDZ domain containing family, member 1, GLUT1CBP, Glut1CIP, Hs.6454, IIP-1, NIP, OPDM2, Rgs19, RGS19IP1, SEMCAP, Semcap1, SYNECTIIN, SYNECTIN, TaxIP2, TIP-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GIPC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin VI binding domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- GIPC homology 2 (GH2) domain-like family
- canonical PDZ domain
- GTPase activator
- protein binding
- receptor binding
- PDZ domain
- proline rich domain
- identical protein binding
- PDZ-domain binding
- myosin binding
- acyl carrier protein domain
- actin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- gastric cancer
- proteinuria
- metastasis
- oculopharyngodistal myopathy type 2
role in cell
- expression in
- binding in
- proliferation
- migration
- morphology
- invasion by
- cytokinesis in
- mitochondrial fission in
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- cell periphery
- postsynaptic region
- membrane surface
- cellular membrane
- retraction fibers
- cell cortex
- Nucleus
- Plasma Membrane
- vesicles
- cytosol
- vesicle membrane
- dendritic spines
- synaptic vesicles
- neurites
- synapse
- cytoplasmic vesicles
- endocytotic vesicle
- brush border
- cellular protrusions
- cell membrane leading edge
- axons
- dendritic shafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GIPC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of melanin biosynthetic process
- protein targeting
- glutamate secretion
- regulation of protein stability
- G-protein coupled receptor signaling pathway
- regulation of synaptic plasticity
- synaptic transmission
- endothelial cell migration
- positive regulation of cytokinesis
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- vesicle membrane
- dendritic shaft
- synaptic vesicle
- cell cortex
- membrane
- dendritic spine
- cytosol
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- actin binding
- cadherin binding
- myosin binding
- receptor binding