PAG1 Gene Summary [Human]
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PAG1 |
| Official Name | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 [Source:HGNC Symbol;Acc:HGNC:30043] |
| Ensembl ID | ENSG00000076641 |
| Bio databases IDs | |
| Aliases | phosphoprotein membrane anchor with glycosphingolipid microdomains 1, Csk-binding protein, transmembrane adaptor protein PAG |
| Synonyms | CBP, F730007C19Rik, FLJ37858, LOC108349978, PAG, phosphoprotein associated with glycosphingolipid microdomains 1, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lck-interacting transmembrane adapter 1
- Csk binding site
- extracellular domain
- palmitoylation site
- cytoplasmic domain
- membrane-association domain
- SH2-domain binding
- transmembrane domain
- protein binding
- Phosphoprotein associated with glycosphingolipid-enriched
- transmembrane receptor protein tyrosine kinase adaptor protein
Pathways
Biological processes and signaling networks where the PAG1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neoplasia
- Alzheimer disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- renal cell carcinoma
- renal cell cancer
- schizophrenia
- colorectal adenoma
- colorectal adenoma formation
role in cell
- proliferation
- growth
- number
- activation in
- activation
- cell death
- phosphorylation in
- migration
- formation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- detergent-insoluble fractions
- Cytoplasm
- cytoplasmic face of plasma membrane
- synaptic vesicles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- adaptive immune response
- negative regulation of T cell activation
- regulation of T cell activation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity
- SH2 domain binding