CSK Gene Summary [Human]
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | CSK |
| Official Name | C-terminal Src kinase [Source:HGNC Symbol;Acc:HGNC:2444] |
| Ensembl ID | ENSG00000103653 |
| Bio databases IDs | |
| Aliases | C-terminal Src kinase |
| Synonyms | CSK-1, c-src tyrosine kinase, C-terminal Src kinase, p50CSK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- ATP binding
- protein binding
- phosphotyrosine binding domain
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- transferase
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the CSK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic myeloid leukemia
- precursor B-cell acute lymphoblastic leukemia
- colon cancer
- blast crisis phase chronic myeloid leukemia
- chronic phase chronic myeloid leukemia
- relapsed B cell acute lymphoblastic leukemia
- bladder cancer
- hypertension
- schizophrenia
- colorectal cancer
role in cell
- phosphorylation in
- apoptosis
- expression in
- activation in
- proliferation
- adhesion
- quantity
- formation
- assembly
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- focal adhesions
- Plasma Membrane
- intercellular junctions
- cytosol
- cytoplasmic face of plasma membrane
- membrane rafts
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- T cell costimulation
- adherens junction organization
- negative regulation of cell proliferation
- adaptive immune response
- negative regulation of bone resorption
- protein phosphorylation
- regulation of Fc receptor mediated stimulatory signaling pathway
- negative regulation of Golgi to plasma membrane protein transport
- negative regulation of interleukin-6 production
- negative regulation of low-density lipoprotein particle clearance
- negative regulation of ERK1 and ERK2 cascade
- cellular response to peptide hormone stimulus
- T cell receptor signaling pathway
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- proline-rich region binding
- identical protein binding
- protein tyrosine kinase activity
- protein binding
- protein phosphatase binding
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding
- protein kinase A catalytic subunit binding