HEATR1 Gene Summary [Human]
Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in fibrillar center and mitochondrion. Implicated in pancreatic ductal carcinoma. Biomarker of glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HEATR1 |
| Official Name | HEAT repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:25517] |
| Ensembl ID | ENSG00000119285 |
| Bio databases IDs | |
| Aliases | HEAT repeat containing 1, UTP10, small subunit (SSU) processome component, homolog (yeast) |
| Synonyms | AA517551, B130016L12RIK, BAP28, Heatr1l1, HEAT repeat containing 1, LOC100910568, LOC108348069, LOC284709, RGD1564769, UTP10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HEATR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- U3 small nucleolar RNA-associated protein 10
- protein binding
- BP28CT (NUC211) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pseudo nucleolar organizer
- fibrillar center
- pre-ribosome
- Mitochondria
- nuclear foci
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HEATR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal small subunit biogenesis
- positive regulation of rRNA processing
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- mitochondrion
- membrane
- t-UTP complex
- nucleolus
- 90S preribosome
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- snoRNA binding
- RNA binding
- protein binding