SERPINB3 Gene Summary [Human]
Enables cysteine-type endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Involved in several processes, including autocrine signaling; paracrine signaling; and regulation of cellular protein metabolic process. Located in cytoplasmic vesicle; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SERPINB3 |
| Official Name | serpin family B member 3 [Source:HGNC Symbol;Acc:HGNC:10569] |
| Ensembl ID | ENSG00000057149 |
| Bio databases IDs | |
| Aliases | serpin family B member 3 |
| Synonyms | HBV-BP, HsT1196, SCC, SCCA, SCCA-1, SCCA-PD, serpin family B member 3, SSCA1, T4-A |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine protease inhibitor activity
- viral receptor
- protease binding
- SERine Proteinase INhibitors (serpin) family
- protein binding
- Serpin (serine protease inhibitor)
- reactive serpin loop
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- atopic dermatitis
- cancer
- epithelial cancer
- COVID-19
- spongiosis
- neoplastic cell transformation
- delayed hypersensitive reaction
- epithelial uterine cancer
- cervical cancer
role in cell
- expression in
- cell death
- apoptosis
- binding
- activation in
- migration
- proliferation
- molecular cleavage in
- accumulation in
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- cell surface
- Extracellular Space
- Nucleus
- Plasma Membrane
- cytosol
- nucleoli
- cytoplasmic vesicles
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- negative regulation of JUN kinase activity
- paracrine signaling
- positive regulation of cell proliferation
- negative regulation of proteolysis
- positive regulation of epithelial to mesenchymal transition
- negative regulation of catalytic activity
- negative regulation of endopeptidase activity
- positive regulation of endopeptidase activity
- negative regulation of peptidase activity
- autocrine signaling
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
- vesicle
- cytoplasmic vesicle
- extracellular region
- plasma membrane
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- cysteine-type endopeptidase inhibitor activity
- viral receptor activity
- protease binding