LXN Gene Summary [Human]
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | LXN |
| Official Name | latexin [Source:HGNC Symbol;Acc:HGNC:13347] |
| Ensembl ID | ENSG00000079257 |
| Bio databases IDs | |
| Aliases | latexin |
| Synonyms | ECI, latexin, TCI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LXN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Latexin
- protein binding
- metalloendopeptidase inhibitor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- impaired glucose tolerance
- hepatic steatosis
- insulin resistance
regulates
role in cell
- differentiation
- homeostasis
- ubiquitination in
- cytostasis
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LXN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- detection of temperature stimulus involved in sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding
- metalloendopeptidase inhibitor activity