SENP1 Gene Summary [Human]
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | SENP1 |
| Official Name | SUMO specific peptidase 1 [Source:HGNC Symbol;Acc:HGNC:17927] |
| Ensembl ID | ENSG00000079387 |
| Bio databases IDs | |
| Aliases | SUMO specific peptidase 1 |
| Synonyms | 2310046A20Rik, D15Ertd528e, E330036L07RIK, LOC103692995, SUMO1/sentrin specific peptidase 1, SUMO specific peptidase 1, SuPr-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SENP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO-specific protease
- endopeptidase
- cysteine endopeptidase
- peptidase
- protein binding
- core domain, functional
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the SENP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cancer
- organismal death
- chromosomal instability
- colon epithelial cancer
- Hutchinson-Gilford progeria syndrome
- advanced cancer
- colon adenocarcinoma
- metastasis to bone
role in cell
- cell viability
- activation in
- apoptosis
- expression in
- differentiation
- function
- binding in
- growth
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- focal adhesions
- nucleoplasm
- nuclear envelope
- nuclear speckles
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SENP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- protein desumoylation
- proteolysis
- apoptotic signaling pathway
- regulation of mRNA stability
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- focal adhesion
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- SUMO-specific protease activity
- SUMO-specific endopeptidase activity