USP25 Gene Summary [Human]
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | USP25 |
| Official Name | ubiquitin specific peptidase 25 [Source:HGNC Symbol;Acc:HGNC:12624] |
| Ensembl ID | ENSG00000155313 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 25 |
| Synonyms | EIG19, LOC108348050, ubiquitin specific peptidase 25, USP21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- peptidase
- USP25_USP28_C-like
- protein binding
- Peptidase_C19
- ATPase binding
- ubiquitin thiolesterase
- tankyrase binding domain
- ubiquitin binding domain
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP25 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- neoplasia
- idiopathic generalized epilepsy
- organismal death
- postmenopausal osteoporosis
- papilloma
- papillomatosis
- Down syndrome
role in cell
- expression in
- production in
- phosphorylation in
- invasion by
- growth
- activation in
- proliferation
- migration
- transcription in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein modification process
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein stability
- proteolysis
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- SUMO binding
- ubiquitin protein ligase binding
- protein binding
- ubiquitin binding
- small conjugating protein-specific protease activity
- peptidase activity
- ATPase binding