ARG2 Gene Summary [Human]
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARG2 |
| Official Name | arginase 2 [Source:HGNC Symbol;Acc:HGNC:664] |
| Ensembl ID | ENSG00000081181 |
| Bio databases IDs | |
| Aliases | arginase 2 |
| Synonyms | AII, ARGINASE2, ARGINASE II, arginase type II |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginase
- enzyme binding
- enzyme
- protein binding
- agmatinase
- Arginase-like and histone-like hydrolases
Pathways
Biological processes and signaling networks where the ARG2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- prostate cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- early missed abortion
- pulmonary fibrosis
role in cell
- proliferation
- expression in
- apoptosis
- cell death
- fusion
- production in
- generation in
- metabolism in
- upregulation in
- oxidative phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- microtubules
- mitochondrial matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adaptive immune response
- negative regulation of defense response to bacterium
- striated muscle contraction
- negative regulation of macrophage inflammatory protein 1 alpha production
- ureteric bud development
- innate immune response
- urea cycle
- negative regulation of chemokine (C-C motif) ligand 5 production
- negative regulation of chemokine (C-C motif) ligand 4 production
- positive regulation of cellular senescence
- negative regulation of interleukin-13 production
- nitric oxide biosynthetic process
- negative regulation of type 2 immune response
- regulation of interleukin-1 beta production
- negative regulation of interleukin-17 production
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- negative regulation of tumor necrosis factor production
- arginine catabolic process to ornithine
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- arginase activity
- manganese ion binding