NT5E Gene Summary [Human]
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | NT5E |
| Official Name | 5'-nucleotidase ecto [Source:HGNC Symbol;Acc:HGNC:8021] |
| Ensembl ID | ENSG00000135318 |
| Bio databases IDs | |
| Aliases | 5'-nucleotidase ecto |
| Synonyms | 2210401F01Rik, 5'-NT, 5' NUCLEOTIDASE, 5' nucleotidase, ecto, 5'-nucleotidase ecto, CALJA, CD73, E5NT, ecto-5'-nucleotidase, eN, eNT, NT, NT5, NTE, Nuc |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NT5E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- 5'-nucleotidase
- NAD pyrophosphatase/5'-nucleotidase NadN
- zinc ion binding
- phosphatase
- 5'-nucleotidase, C-terminal domain
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- identical protein binding
- Calcineurin-like phosphoesterase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- locally advanced non-small cell lung cancer
- pulmonary fibrosis
- metastasis
- dextran sodium sulfate-induced colitis
- advanced cancer
- cancer
- colorectal cancer
- biliary tract disease
- calcification of joints and arteries
role in cell
- phosphorylation in
- expression in
- activation
- quantity
- migration
- invasion by
- proliferation
- cell death
- degradation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- extracellular vesicles
- reticular fibers
- cell surface
- microvesicles
- intracellular membranes
- cellular membrane
- endosomes
- cytosol
- apical cell surfaces
- plasma membrane extracellular face
- apical membrane
- synaptic membrane
- basolateral membrane
- nucleoplasm
- nerve ending
- basal lamina
- membrane rafts
- detergent insoluble microdomains
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NT5E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenosine biosynthetic process
- ADP catabolic process
- calcium ion homeostasis
- AMP catabolic process
- response to ATP
- negative regulation of inflammatory response
- ATP metabolic process
- DNA metabolic process
- leukocyte cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- external side of plasma membrane
- cytosol
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- identical protein binding
- zinc ion binding
- protein binding
- 5'-nucleotidase activity
- GMP 5'-nucleotidase activity
- thymidylate 5'-phosphatase activity
- IMP 5'-nucleotidase activity