AK6 Gene Summary [Human]

This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Details

Type
Protein Coding
Official Symbol
AK6
Official Name
adenylate kinase 6 [Source:HGNC Symbol;Acc:HGNC:49151]
Ensembl ID
ENSG00000085231
Bio databases IDs NCBI: 102157402 Ensembl: ENSG00000085231
Aliases adenylate kinase 6, coilin interacting nuclear ATPase protein
Synonyms 2810046E22Rik, 4921516M08Rik, AD-004, adenylate kinase 6, AK/ATPase, CGI-137, CINAP, CIP, hCINAP
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AK6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • kinase
  • shikimate kinase
  • nucleoside-phosphate kinase
  • adenylate kinase
  • NK
  • UMP-CMP kinase family
  • N-terminal helicase domain of the DEAD-box helicase superfamily
  • protein binding
  • P-loop containing Nucleoside Triphosphate Hydrolases
  • AAA domain

Pathways

Biological processes and signaling networks where the AK6 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
  • nucleoside
  • nitrogenous base
  • nucleotide
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • centrosome
  • nucleoplasm
  • nuclear speckles
  • Cajal bodies

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human AK6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • nucleobase-containing small molecule interconversion
  • ribosomal small subunit biogenesis
  • nucleoside monophosphate phosphorylation
  • rRNA processing

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • centrosome
  • cytoplasm
  • nuclear speck
  • membrane
  • Cajal body
  • nucleolus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • nucleoside phosphate kinase activity
  • ATPase activity
  • ATP binding
  • adenylate kinase activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.