IPO11 Gene Summary [Human]
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | IPO11 |
| Official Name | importin 11 [Source:HGNC Symbol;Acc:HGNC:20628] |
| Ensembl ID | ENSG00000086200 |
| Bio databases IDs | |
| Aliases | importin 11 |
| Synonyms | 1700081H05Rik, 2510001A17Rik, E330021B14Rik, IMP11, importin 11, LOC683676, RanBP11, SLRN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IPO11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Importin-beta N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver neoplasia
- epithelial cancer
- liver cancer
- neonatal late-onset sepsis
- acute myeloid leukemia
- COVID-19
role in cell
- dipeptide repeat protein sensitivity
- signaling in
- transport in
- JQ1 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IPO11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
- ribosomal protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding