SEPHS1 Gene Summary [Human]
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | SEPHS1 |
| Official Name | selenophosphate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:19685] |
| Ensembl ID | ENSG00000086475 |
| Bio databases IDs | |
| Aliases | selenophosphate synthetase 1, selenide, water dikinase |
| Synonyms | 1110046B24Rik, SELD, selenophosphate synthetase 1, SPS, SPS1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEPHS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- selenide, water dikinase
- AIR synthase related protein, N-terminal domain
- selenium donor protein
- ATP binding
- protein homodimerization
- PurM-like
- enzyme
- protein binding
- identical protein binding
- protein heterodimerization
- AIR synthase related protein, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEPHS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- selenocysteine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- identical protein binding
- protein binding
- selenide, water dikinase activity
- metal ion binding