Sephs1 Gene Summary [Mouse]
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and selenide, water dikinase activity. Predicted to be involved in selenocysteine biosynthetic process. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SEPHS1 (selenophosphate synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sephs1 |
| Official Name | selenophosphate synthetase 1 [Source:MGI Symbol;Acc:MGI:1923580] |
| Ensembl ID | ENSMUSG00000026662 |
| Bio databases IDs | |
| Aliases | selenophosphate synthetase 1 |
| Synonyms | 1110046B24Rik, SELD, selenophosphate synthetase 1, SPS, SPS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sephs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- selenide, water dikinase
- AIR synthase related protein, N-terminal domain
- selenium donor protein
- ATP binding
- protein homodimerization
- PurM-like
- enzyme
- protein binding
- identical protein binding
- protein heterodimerization
- AIR synthase related protein, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sephs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- selenocysteine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- identical protein binding
- protein binding
- selenide, water dikinase activity
- metal ion binding