CEACAM6 Gene Summary [Human]
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | CEACAM6 |
| Official Name | CEA cell adhesion molecule 6 [Source:HGNC Symbol;Acc:HGNC:1818] |
| Ensembl ID | ENSG00000086548 |
| Bio databases IDs | |
| Aliases | CEA cell adhesion molecule 6 |
| Synonyms | CD66c, CEA cell adhesion molecule 6, CEAL, NCA, NCA-50/90 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEACAM6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- identical protein binding
- protein heterodimerization
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- breast cancer
- septic shock
- gastrointestinal neoplasia
- tubulovillous adenoma
- mixed neoplasia
- adenoma formation
- edema
- primary ovarian cancer
- tubular adenoma
role in cell
- apoptosis
- proliferation
- migration
- adhesion
- invasion by
- invasion
- internalization by
- activation
- anoikis
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- microvesicles
- cellular membrane
- secretory granule membrane
- apical membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEACAM6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of anoikis
- signal transduction
- apoptotic process
- positive regulation of cell proliferation
- heterophilic cell-cell adhesion
- positive regulation of heterotypic cell-cell adhesion
- homophilic cell adhesion
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- azurophil granule membrane
- plasma membrane
- apical plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein heterodimerization activity