CSTF2 Gene Summary [Human]
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CSTF2 |
| Official Name | cleavage stimulation factor subunit 2 [Source:HGNC Symbol;Acc:HGNC:2484] |
| Ensembl ID | ENSG00000101811 |
| Bio databases IDs | |
| Aliases | cleavage stimulation factor subunit 2 |
| Synonyms | C630034J23Rik, cleavage stimulation factor, 3' pre-RNA subunit 2, cleavage stimulation factor subunit 2, CSTF64, CSTF 64 kDa subunit, mir-3112, XLID113 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSTF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyadenylate binding protein, human types 1, 2, 3, 4 family
- Transcription termination and cleavage factor C-terminal
- Hinge domain of cleavage stimulation factor subunit 2
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- poly-U binding splicing factor, half-pint family
- RNA binding
Pathways
Biological processes and signaling networks where the CSTF2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear foci
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
- cleavage bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSTF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nuclear body
- mRNA cleavage and polyadenylation specificity factor complex
- cleavage body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding