TXLNG Gene Summary [Human]
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | TXLNG |
| Official Name | taxilin gamma [Source:HGNC Symbol;Acc:HGNC:18578] |
| Ensembl ID | ENSG00000086712 |
| Bio databases IDs | |
| Aliases | taxilin gamma, lipopolysaccharide specific response-5 protein, factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription |
| Synonyms | 4932441K18, 4932441K18Rik, CXorf15, ELRG, FIAT, Lrp, LSR5, taxilin gamma, taxilin γ, TXLNGX |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TXLNG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myosin-like coiled-coil protein
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- T acute lymphoblastic leukemia
- Turner syndrome
- Klinefelter syndrome
role in cell
- mineralization
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TXLNG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell cycle
- regulation of bone mineralization
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- syntaxin binding