LPCAT2 Gene Summary [Human]
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | LPCAT2 |
| Official Name | lysophosphatidylcholine acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:26032] |
| Ensembl ID | ENSG00000087253 |
| Bio databases IDs | |
| Aliases | lysophosphatidylcholine acyltransferase 2 |
| Synonyms | 1-Acylglycerophosphocholine O-acyltransferase, 1-AGPAT 11, A330042H22, AGPAT11, AYTL1, Aytl1a, lpafat1, LPLAT9, LysoPAFAT, lysoPAFAT/LPCAT2, lysophosphatidylcholine acyltransferase 2, RGD1563994 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LPCAT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- 1-acylglycerol-3-phosphate O-acyltransferase
- EF-hand domain pair
- 1-acylglycerophosphocholine O-acyltransferase
- EFh
- enzyme
- protein binding
- EF-hand domain
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- EF hand
- 2-acylglycerol-3-phosphate O-acyltransferase
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- Acyltransferase
- 1-alkylglycerophosphocholine O-acetyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- squamous cell lung cancer
- breast cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- rectum cancer
- colon epithelial cancer
- colorectal cancer
- glioblastoma
role in cell
- organization
- binding in
- expression in
- proliferation
- transactivation in
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- endoplasmic reticulum membrane
- microsome
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LPCAT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- phosphatidylcholine acyl-chain remodeling
- platelet activating factor biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- endoplasmic reticulum
- Golgi membrane
- Golgi stack
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- lysophosphatidic acid acyltransferase activity
- 1-acylglycerophosphocholine O-acyltransferase activity
- protein binding
- calcium ion binding
- 2-acylglycerol-3-phosphate O-acyltransferase activity
- 1-alkenylglycerophosphocholine O-acyltransferase activity
- 1-alkylglycerophosphocholine O-acetyltransferase activity