SIRPG Gene Summary [Human]
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SIRPG |
| Official Name | signal regulatory protein gamma [Source:HGNC Symbol;Acc:HGNC:15757] |
| Ensembl ID | ENSG00000089012 |
| Bio databases IDs | |
| Aliases | signal regulatory protein gamma |
| Synonyms | bA77C3.1, CD172g, LOC100131600, signal regulatory protein gamma, signal regulatory protein γ, SIRP-B2, SIRP gamma, SIRPG isoform 2, SIRP γ |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIRPG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- insulin-dependent diabetes mellitus
- cerebral aneurysm
- diabetic nephropathy
- narcolepsy with cataplexy
role in cell
- expression in
- proliferation
- phosphorylation in
- activation
- phagocytosis
- phagocytosis by
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIRPG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell activation
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- positive regulation of cell-cell adhesion
- cell-cell signaling
- cell adhesion
- positive regulation of phagocytosis
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding