STK4 Gene Summary [Human]
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STK4 |
| Official Name | serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408] |
| Ensembl ID | ENSG00000101109 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 4, mammalian sterile 20-like 1, yeast Ste20-like, kinase responsive to stress 2, hippo (Drosophila) homolog |
| Synonyms | Kas-2, KRS2, MST1, serine/threonine kinase 4, YSK3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- ATP binding
- transcription factor binding
- inhibitory domain
- Protein kinase domain
- identical protein binding
- SARAH domain
- N-terminal kinase domain
- ABC1 atypical kinase-like domain
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- dimerization domain
- Akt phosphorylation site
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- inhibitory dimerization domain
- protein binding
- magnesium ion binding
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- SARAH_SF
- kinase domain
- Protein Kinases, catalytic domain
- C terminal SARAH domain of Mst1
- protein homodimerization
Pathways
Biological processes and signaling networks where the STK4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- cancer
- schizophrenia
- epithelial cancer
- streptozotocin-induced diabetes
- chromosome 20q deletion positive myelofibrosis
- T-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations
- colorectal cancer
- hyperplasia
role in cell
- morphology
- quantity
- activation in
- proliferation
- survival
- differentiation
- expression in
- phosphorylation in
- apoptosis
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- microtubules
- cytosol
- nucleoplasm
- nuclear bodies
- spindle pole
- membrane rafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organ growth
- regulation of MAPK cascade
- positive regulation of protein binding
- regulation of cell differentiation involved in embryonic placenta development
- positive regulation of fat cell differentiation
- protein autophosphorylation
- protein phosphorylation
- induction of apoptosis via death domain receptors
- endocardium development
- neural tube formation
- epithelial cell proliferation
- cell differentiation involved in embryonic placenta development
- patterning of blood vessels
- protein tetramerization
- apoptotic process
- canonical Wnt receptor signaling pathway
- intracellular signal transduction
- positive regulation of peptidyl-serine phosphorylation
- signal transduction
- cell morphogenesis
- negative regulation of organ growth
- primitive hemopoiesis
- hepatocyte apoptotic process
- negative regulation of canonical Wnt receptor signaling pathway
- keratinocyte differentiation
- central nervous system development
- protein import into nucleus
- positive regulation of apoptotic process
- positive regulation of protein phosphorylation
- negative regulation of epithelial cell proliferation
- hippo signaling cascade
- peptidyl-serine phosphorylation
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein serine/threonine kinase activator activity
- protein binding
- protein homodimerization activity
- protein kinase activity
- protein serine/threonine kinase activity