LATS1 Gene Summary [Human]
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Details
| Type | Protein Coding |
| Official Symbol | LATS1 |
| Official Name | large tumor suppressor kinase 1 [Source:HGNC Symbol;Acc:HGNC:6514] |
| Ensembl ID | ENSG00000131023 |
| Bio databases IDs | |
| Aliases | large tumor suppressor kinase 1 |
| Synonyms | AC156391.6, AW208599, large tumor suppressor, large tumor suppressor kinase 1, large tumour suppressor, large tumour suppressor kinase 1, RGD1564085, WARTS, wts |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LATS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein kinase C terminal domain
- catalytic domain
- PPXY motif
- Protein tyrosine and serine/threonine kinase
- ATP binding
- estrogen receptor binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- proline tyrosine motif
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- basic domain
- Tyrosine kinase, catalytic domain
- Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
Pathways
Biological processes and signaling networks where the LATS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- neoplasia
- epithelial cancer
- plasma cell myeloma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- neoplastic cell transformation
- chromosomal instability
- skin basal cell carcinoma
role in cell
- cell death
- apoptosis
- growth
- differentiation
- phosphorylation in
- binding in
- morphology
- expression in
- production in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- centrosome
- midbody
- microtubule organizing centers
- cytosol
- spindle pole
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LATS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid segregation
- protein phosphorylation
- mammary gland epithelial cell differentiation
- hormone-mediated signaling pathway
- cell division
- G2/M transition of mitotic cell cycle
- cytoplasmic sequestering of protein
- G1/S transition of mitotic cell cycle
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- inner cell mass cell fate commitment
- inner cell mass cellular morphogenesis
- positive regulation of peptidyl-serine phosphorylation
- negative regulation of protein localization to nucleus
- regulation of protein complex assembly
- regulation of organ growth
- negative regulation of cyclin-dependent protein kinase activity
- regulation of actin filament polymerization
- negative regulation of canonical Wnt receptor signaling pathway
- keratinocyte differentiation
- positive regulation of apoptotic process
- regulation of intracellular estrogen receptor signaling pathway
- hippo signaling cascade
- regulation of transforming growth factor beta receptor signaling pathway
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- spindle pole
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein kinase binding
- ATP binding
- protein binding
- estrogen receptor binding
- protein serine/threonine kinase activity