GCN1 Gene Summary [Human]
Enables RNA binding activity and cadherin binding activity. Predicted to be involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GCN1 |
| Official Name | GCN1 activator of EIF2AK4 [Source:HGNC Symbol;Acc:HGNC:4199] |
| Ensembl ID | ENSG00000089154 |
| Bio databases IDs | |
| Aliases | GCN1 activator of EIF2AK4 |
| Synonyms | 4932409G22, G431004K08RIK, GCN1 activator of EIF2AK4, GCN1L, GCN1L1, mKIAA0219, PRIC295 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- HEAT-like repeat
- protein kinase regulator
- protein binding
- enzyme regulator activity
- HEAT repeats
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ribosome
- cytosol
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- rescue of stalled ribosome
- cellular response to amino acid starvation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- ribosome
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein serine/threonine kinase activator activity
- cadherin binding
- translation factor activity, nucleic acid binding
- protein kinase regulator activity
- binding, bridging