Gcn1 Gene Summary [Mouse]
Enables protein serine/threonine kinase activator activity. Involved in GCN2-mediated signaling and cellular response to amino acid starvation. Located in cytoplasm. Is expressed in several structures, including gut; heart; hemolymphoid system gland; liver; and lung. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gcn1 |
| Official Name | GCN1 activator of EIF2AK4 [Source:MGI Symbol;Acc:MGI:2444248] |
| Ensembl ID | ENSMUSG00000041638 |
| Bio databases IDs | |
| Aliases | GCN1 activator of EIF2AK4 |
| Synonyms | 4932409G22, G431004K08RIK, GCN1 activator of EIF2AK4, GCN1L, GCN1L1, mKIAA0219, PRIC295 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gcn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- HEAT-like repeat
- protein kinase regulator
- protein binding
- enzyme regulator activity
- HEAT repeats
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ribosome
- cytosol
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gcn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- rescue of stalled ribosome
- cellular response to amino acid starvation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- ribosome
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein serine/threonine kinase activator activity
- cadherin binding
- translation factor activity, nucleic acid binding
- protein kinase regulator activity
- binding, bridging